Diversity of T cell epitopes in Plasmodium falciparum circumsporozoite protein likely due to protein-protein interactions.
Circumsporozoite protein (CS) is a leading vaccine antigen for falciparum malaria, but is New Arrivals highly polymorphic in natural parasite populations.The factors driving this diversity are unclear, but non-random assortment of the T cell epitopes TH2 and TH3 has been observed in a Kenyan parasite population.The recent publication of the crystal